Guide to High-Dose Methotrexate Monitoring and Leucovorin Rescue Management
A practical guide for the clinical management of high-dose methotrexate in onco-hematology patients. The document outlines key elements to ensure safe and effective treatment, including:
Supportive measures prior to methotrexate administration
Monitoring of methotrexate plasma concentrations
Strategies for optimizing leucovorin rescue
Management of methotrexate-related toxicity
Clinical decision algorithms for different scenarios
Guidance for centres without specialized pharmacokinetic support
Answers to common questions encountered during therapeutic monitoring
